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This mitochondrial fission triggers an upregulation of CHAC1/BOTCH through the transcription factor NRF2 and ROS signaling, which in turn inhibits stem cell self-renewal and promotes cell differentiation (Khacho et al., 2016)
The gastric stability of BPC-157 is a distinguishing feature most peptides are rapidly degraded by pepsin and hydrochloric acid in gastric fluid
[PubMed ID: 18825537]
Peptides can bind to cells and signal them to do specific things
Thus, drugs regulating ubiquitin expression after spinal injury could have the potential to spare neurons from injury by minimizing A accumulation (Yokobori et al., 2015)
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